Cajun Chicken Alfredo Fettuccine

Featured in: Evening Suppers

This dish features juicy, Cajun-spiced chicken breasts paired with fettuccine tossed in a smooth Velveeta and Parmesan cheese sauce. Aromatic garlic and a touch of cayenne add depth and warmth, creating a comforting pasta blend. The creamy sauce coats the noodles perfectly, with fresh parsley garnish adding brightness. It’s a flavorful, easy-to-make meal combining Southern heat with classic creamy textures.

Updated on Sun, 23 Nov 2025 08:33:00 GMT
Close-up of Cajun Chicken Alfredo Fettuccine: creamy pasta with spicy chicken and fresh parsley garnish. Save
Close-up of Cajun Chicken Alfredo Fettuccine: creamy pasta with spicy chicken and fresh parsley garnish. | moonthyme.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This dish quickly became a family favorite for weeknight dinners thanks to its ease and bold flavors.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts 1 ½ tablespoons Cajun seasoning 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter 2 cloves garlic minced 1 cup (240 ml) heavy cream 8 oz (225 g) Velveeta cheese cubed ½ cup (50 g) grated Parmesan cheese ½ teaspoon black pepper ¼ teaspoon cayenne pepper (optional for extra heat) Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet heat olive oil over medium-high heat. Add chicken and cook 5 6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
Sizzling Cajun-seasoned chicken slices atop fettuccine Alfredo, a delicious Velveeta sauce delight. Save
Sizzling Cajun-seasoned chicken slices atop fettuccine Alfredo, a delicious Velveeta sauce delight. | moonthyme.com

This recipe brings the family together with its comforting and spicy profile every time we make it.

Notes

Pairs well with a crisp green salad and a chilled Chardonnay. Add sautéed bell peppers or mushrooms for extra flavor and color.

Required Tools

Large pot Large skillet Knife and cutting board Tongs or pasta fork Measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter). Contains wheat (fettuccine). Contains chicken. Those with allergies should check ingredient labels for hidden allergens.

Bright photo of Cajun Chicken Alfredo Fettuccine, a flavorful meal with tender chicken and creamy sauce. Save
Bright photo of Cajun Chicken Alfredo Fettuccine, a flavorful meal with tender chicken and creamy sauce. | moonthyme.com

This Cajun Chicken Alfredo is a guaranteed crowd-pleaser ready in under an hour.

Recipe FAQ

How do I ensure the chicken stays tender?

Pat the chicken dry before seasoning and cook over medium-high heat until golden to seal in juices, then let it rest before slicing.

Can I substitute Velveeta cheese?

Yes, you can use a mild processed cheese or blend mozzarella with cream for a similar creamy texture.

How to adjust the spiciness of the dish?

Modify the amount of Cajun seasoning or cayenne pepper according to your heat preference.

What is the best way to keep the sauce smooth?

Stir the sauce frequently while melting cheese, and add reserved pasta water gradually to loosen consistency.

Can I add vegetables to this dish?

Sautéed bell peppers or mushrooms work well to enhance flavor and add color to the pasta.

Cajun Chicken Alfredo Fettuccine

Tender chicken and spicy cheese sauce blend with fettuccine for a creamy Southern-inspired dish.

Prep Time
15 min
Time to Cook
25 min
Total Duration
40 min
Created by Lydia Brooks


Skill Level Easy

Cuisine American (Cajun-inspired)

Portions 4 Serving Size

Diet Info None specified

What You'll Need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 ounces Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

How to Make It

Step 01

Cook Pasta: Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain, reserving ½ cup pasta water, and set pasta aside.

Step 02

Prepare Chicken: Pat chicken breasts dry and season both sides evenly with Cajun seasoning.

Step 03

Cook Chicken: Heat olive oil in a large skillet over medium-high heat. Sear chicken 5 to 6 minutes per side until golden and cooked through (internal temperature 165°F). Remove and let rest for 5 minutes, then slice thinly.

Step 04

Sauté Garlic: Reduce skillet heat to medium. Add butter and minced garlic, sautéing for 1 minute until fragrant.

Step 05

Prepare Sauce: Gradually stir in heavy cream, bringing it to a gentle simmer. Add Velveeta cheese cubes, stirring until fully melted and smooth.

Step 06

Finish Sauce: Incorporate grated Parmesan, black pepper, cayenne pepper (if using), and salt to taste. Adjust consistency by adding reserved pasta water a little at a time to reach a creamy texture.

Step 07

Combine Pasta and Sauce: Toss the cooked fettuccine in the sauce until evenly coated.

Step 08

Serve: Plate the pasta, top with sliced Cajun chicken, and garnish with chopped parsley and extra Parmesan cheese if desired.

Tools Needed

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergen Details

Review every ingredient for allergens and ask a medical professional when unsure.
  • Contains milk/dairy from Velveeta, Parmesan, cream, and butter.
  • Contains wheat from fettuccine pasta.
  • Contains poultry.

Nutrition Details (each serving)

These details are for reference only, and shouldn't replace healthcare advice.
  • Energy: 670
  • Fats: 32 g
  • Carbohydrates: 57 g
  • Proteins: 41 g